TNF - Tumour Necrosis Factor

Tumour Necrosis Factor and Apoptosis

Also known as TNF-a
Major inflammatory cytokine; cytokine is a product of white blood cells
Was used on mice and rabbits to cure solid tumours however, it cannot be used in humans because it is toxic
Serum TNF-a is elevated in end-stage AIDS
Biological assy to measure bio-active

TNF- induced cell death in presence of cycloheximide or actinomycin D which inhibits protein synthesis (transcription phase)